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In fact, it has been known since the 1990s that blocking dopamine transmission takes away the reward effects of some addictive substances, such as cocaine and amphetamines.[ref] There are three theories on how dopamine is related to addiction

The combination protocol increases the number of dose escalation events (since you are titrating two compounds), which may mean more frequent but generally mild headaches

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Emotion: Dopamine is also important in emotions

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This economic advantage reflects reduced healthcare costs, decreased worker compensation claims, and improved productivity outcomes (123)