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The ligands were bound to D106 according to the crystal structures using the [intermolecular_interactions] block of GROMACS with a bond length of 0.185 nm, a force constant of 10 5 kJ mol 1 nm 2 and bond type 6

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Vi cc khch tnh, Qu khch c th chuyn hng qua bu in & Lin h vi Vinbeauty v sn phm i, m bu in, Vinbeauty c th x l v gi hng li sm nht khi nhn c sn phm

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F.van CranenbroekB.ter MeerM.DonckersJ.ScholtenR

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doi: 10.1038/s42255-025-01245-6 108 Mazloum-RavasanSMadadiEMohammadiAMansooriBAminiMMokhtarzadehAet al

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For acute OIPN, the dysfunction of ion channels, OCT protein, and glial cells are involved in the acute pain, whereas the main mechanisms relevant to chronic OIPN are nuclear DNA damage, oxidative stress-induced mitochondrial damage, glia activation-related neuroinflammation, and gut microbiota-induced inflammation (Fig

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