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In this context, it would be important to investigate in future studies whether chronic EtOH fed WT and KO mice differ in the gastric metabolism of ethanol

J Neuroimmunol 2004, 147: 4349

Luc E Gosselin, Lauren Chrapowitzky, Todd C Rideout (2019 Sep) Metabolic effects of -lipoic acid supplementation in pre-diabetics: a randomized, placebo-controlled pilot study

Meister, Amino acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine synthetase

In a 26-week study, orforglipron demonstrated a significant dose-dependent effect on weight loss, with weight reduction ranging from 8.6% to 12.6% across various dosages, compared to only 2.0% in the placebo group

Therefore, it can be expected that screening more appropriate target genes can effectively increase the ATP generation efficiency for the enhanced production of GSH