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The effects of NTZ were compared to those of the standard antioxidant, N-acetyl cysteine (NAC), as a well-documented hepatoprotective agent known to inhibit ER stress, and to those of 4-phenyl butyrate (4-PBA), a standard ER stress inhibitor ( 2 Materials and methods 2.1 The experimental animals Currently, we included 36 adult male albino Wistar rats (with a body mass range equal to 190230 g, 810 weeks of age) supplied by the Faculty of Veterinary Medicine, Zagazig University. Rats were kept in hygienic laboratory conditions, including temperature (22C 3C), relative humidity (60% 10%), and normal light/dark cycle

58-93-5) in F344/N rats and B6C3F1 mice (feed studies)

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Net Contents: 325 mg x 30 sheets (9.75 g)

doi: 10.1007/s13668-018-0237-y 162 LiewS-C

Figure 6 presents the simulated fate of a single 50 M doxorubicin exposure (top panel), as well as the subsequent O 2 . and H 2 O 2 profiles, over a 30-minute time-span