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This review aims to fill these gaps by offering a comprehensive assessment of GSHs dual role in cancer biology, systematically examining nanotechnology-enabled approaches (such as disulfide and diselenide linkages, transition metal systems, and prodrugs), and critically evaluating their strengths, limitations, and potential for clinical translation

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Barbosa, M

The integrin 1/5/JNK/c-JUN signaling pathway in cancer cells is able to upregulate the higher matrix stiffness-induced lysyl oxidase like (LOXL)-2, then subsequently promote production of fibronectin, expression of MMP-9 and C-X-C motif chemokine ligand (CXCL)-12 and recruitment of BMDCs to encourage pre-metastatic niche establishment (95)