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Primary and immortalised adipocyte models document effects on lipolysis (enhanced by glucagon receptor activation), browning markers (uncoupling protein 1, PGC-1), and thermogenic gene expression

Garcia-Echeverria et al (2004) presented a new compound (a pyrrolo[2,3-d] pyrimidine) that although inhibiting the IGF-1R and IR TK equipotently in cell-free systems, exhibited several-fold selectivity for the IGF-1R in a cellular context and reduced the growth of IGF-1R positive fibrosarcomas in vivo

We demonstrated that constitutive activation of NRF2/CBS signalling conferred erastin-induced ferroptosis resistance

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