The tissue under the tongue (sublingual mucosa) is highly vascular and permeable, allowing molecules to pass directly into the bloodstream without first encountering stomach acid or liver metabolism
Waizenegger IC, Lu H, Thamer C, Savarese F, Gerlach D, Rudolph D, Vellano CP, Marotti M, Heymach J, Kopetz S , Heffernan TP, Marszalek JR, Petronczki MP, Hofmann MH, Kraut N
Honestly, the risk-to-reward ratio for deep localized injections is a difficult calculation
Importantly, nasal sprays enable rapid absorption through the nasal mucosa, allowing the peptide to bypass first-pass metabolism and enter systemic circulation with greater efficiency
Bruno, B
Patients in the Miami area should expect a multi-modal approach