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However, excessive doses deplete glutathione stores allowing NAPQI to damage the cell, particularly mitochondria [64,65]

At weekly intervals, randomly selected individuals were removed from the aquarium by hand and transferred into individual beakers (diameter, 70 mm) with fresh sterile seawater washed sand, seawater was added, and burrowing time was recorded

Supplemental pyridoxine injections might be advised in these cases

A single protocol addresses problems throughout the body rather than requiring multiple targeted interventions