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DMSO-based solutions exhibited the highest retention of activity but raised concerns about in vivo toxicity

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Therefore, neuronal subsets (iSPNs) from mouse striatal tissues of mutants and controls (here called iSPN + mut and iSPN + wt populations, respectively) were genetically labelled in vivo with a fluorescent marker using Rosa26-Ai9-tdTomato strain 21 and purified by fluorescence-activated cell sorting

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Ascorbate peroxidase (APX), glutathione peroxidase (GPX), and catalase (CAT) are the main enzymes responsible for suppressing toxic levels of H 2 O 2 (Apel and Hirt, 2 O 2 decomposition (Anjum et al., 2015)