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In pancreatic ductal adenocarcinoma, lactate accumulation fuels the enrichment of histone H3 lysine-18 lactylation (H3K18la) at the promoters of TTK and BUB1B, generating a glycolysisH3K18laTTK/BUB1B positive-feedback circuit that persistently augments glucose uptake and lactate production, thereby reinforcing aerobic glycolysis [90]

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205 Allopurinol is a purine analog that acts as a suicide inhibitor of XO, meaning it irreversibly binds to the enzyme and prevents it from generating uric acid

10.4161/auto.6.7.12754 Autophagy 50 FilomeniG.PiccirilloS.RotilioG.CirioloM

1 2 3 "High-Ranking Mexican Cartel Leader Arrested on Charges of International Drug Trafficking and Money Laundering After Faking Own Death to Live in California Under Assumed Identity"

JCI Insight 4 , e121291 (2019)