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However, reduced dietary intake due to appetite suppression and gastrointestinal side effects may indirectly increase deficiency risk, particularly if consumption of B12-rich animal products decreases significantly

Common reasons include: Pernicious anemia , an autoimmune condition affecting intrinsic factor production Gastrointestinal disorders, such as Crohns disease or celiac disease Prolonged use of certain medications, like proton pump inhibitors Knowing these causes helps spot at-risk people

It also supports muscle function and heart health

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R., & Annamaraju, P

Severe neurological deficiency may require daily injections initially, tapering to monthly maintenance