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[4] A fourth route, intranasal delivery, has been explored in the context of neurological applications on the premise that the nasal mucosa provides a direct pathway to the central nervous system via the olfactory nerve

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D57 (CTR) and D254 (G), were predicted protonated, however, visual inspection did not support this prediction because of their solvent-exposed location and, therefore, were modelled in the anionic side chain form

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