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In contrast, the intracellular methionine and cysteine levels were dramatically reduced to ~0.3% and undetectable, respectively, after 1 h of methionine/cystine restriction in both HepG2 and SNU449 cells (Supplementary Fig

To analyze the reduced methionine cycle further, we built a simplified methionine cycle motif (Figure 2B): An even simpler, stylized model that reflects the topology of the reduced model

PubMed, doi:10.1016/j.jpba.2019.04.048

Plasma homocysteine predicts mortality independently of traditional risk factors and C-reactive protein in patients with angiographically defined coronary artery disease

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