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It has been found that HHcy may be directly or indirectly associated with the development of hypothyroidism, but the findings with hyperthyroidism, chronic lymphocytic thyroiditis and reduced thyroid hormone sensitivity are controversial

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The male SHR model showed that intestinal flora and its metabolites are closely associated with hypertension-related nephropathy, and the results indicate that reduced levels of SCFAs, inflammatory factor release, and blood pressure disturbances occur in the process (174)

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