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We used the GSH/GSSG-Glo Assay to monitor GSH changes in the cells dosed with BSO (Figure 5, Panel B)

This cytotoxic defense system exposes the pathogen to reactive oxygen species (ROS)

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While ROS typically enhances IL-1 and IL-10 expression, SLC25A40 knockdown paradoxically reduced IL-1 and IL-10 transcription despite increased ROS levels