J Neurol Neuromed
Chucair AJ, Rotstein NP, Sangiovanni JP, During A, Chew EY, Politi LE
Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau
Something else to consider when choosing NAD+ vs
Our genetic, transcriptomic and metabolic profiling analyses together reveal a connection between cytosolic glyoxylate and a non-canonical photorespiratory route mediated by HPR2, which we name the photorespiratory glyoxylate shunt
Keep in mind that evidence is preliminary and largely based on animal studies or small human trials