Nrf2 has been found in high abundance in biopsies of rapidly dividing cancer cells with bad responses to chemotherapy
Because human cells cannot store any significant amount of folate but the liver can store 3-6 years worth of B12, folate deficient megaloblastic anemias manifest very quickly, whereas B12 deficient anemias take considerably longer to manifest
Notably, induction of inflammatory mediators also occurs in BBB ECs, suggesting the progression of inflammation from glia to cerebral microvessels
No waste from expiration
However, response may vary: Higher baseline weight Individuals starting at higher body weights may experience: Slower percentage weight loss initially Need for full maintenance doses to achieve optimal effects Potentially better tolerance of higher doses Lower baseline weight Those with lower starting weights might: Achieve therapeutic goals at submaximal doses (e.g., 2.4 mg vs
Obviously, if there's any sort of vagal nerve dysfunction, you're stuck in this dysautonomic sympathetic driven state
