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treated the patients included in the study, prospectively documented their outcomes, and contributed to clinical oversight, sample procurement, and study coordination

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Hydrochloric acid and/or sodium hydroxide may have been added during manufacture to adjust the pH (range 4.5-7.0)

Smoking impairs wound healing through vasoconstriction, reduced oxygen delivery, and impaired immune function

The latter interacts with vitamin D receptors (VDR)

Months six through twelve bring continued improvement