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When B12 levels become problematic: High-dose supplementation (particularly doses exceeding 1,000 micrograms daily) Frequent B12 injections without medical supervision Underlying conditions affecting B12 metabolism Concurrent use of multiple B12-containing supplements The NHS does not set an upper safe limit for vitamin B12 because harmful effects from excessive intake have not been definitively established
Millions of people have a B12 deficiency
Defyne and Refyne are very similar, but Defyne is firmer and that means if you place it too close to the surface, youll be able to feel it, which is not ideal
Because injections skip this step, the absorption rate of B12 is significantly higher and more predictable than oral supplements
Consistency over the full protocol duration matters more than individual dose precision
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