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So, DR may extend lifespan in part by preventing the aging-induced oxidation of these cytoplasmic redox ratios in C57BL/6N mice and by enhancing the aging-related reductive shifts in these cytoplasmic redox ratios in C57BL/6J mice

Several reasons may explain this phenomenon

Nabulsi N, Abdallah CG, Yang J, Parsey R V, Carson RE, Delorenzo C

EMBO J 36(15):22332250 Kopacz A, Kloska D, Forman HJ, Jozkowicz A, Grochot-Przeczek A, Elsevier Inc

The apparent conflicts were covered by multiple news outlets and were reportedly the subject of concern by some FDA staff members

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