The FDA applied a four-part statutory test under 21 CFR 216.23(c): physical and chemical characterization, historical compounding use, evidence of effectiveness, and safety
Later knowing the selenoprotein nature and primary structure of TrxR1 we also showed that the selenocysteine-containing motif in fact was the primary target for dinitrophenyl-derivatization and that the NADPH oxidase activity produced superoxide
Timshel, P
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The Free Radical Theory of Aging Matures
