By modulating the activity of key immune cells and pathways, zinc supplementation emerges as a promising approach to strengthen immunity, reduce oxidative stress, and counteract "inflammaging," a state of chronic, low-grade inflammation that accelerates tissue damage and drives disease progression
doi: 10.1016/j.ijpharm.2009.04.050, 169
Fireground Specific Nutrition Practices: Pre/Post Exposure Pre-Incident Hydrate before and during shift Maintain good electrolyte balance Consume antioxidant rich foods Avoid ultra-processed foods that can add xenobiotic burden Support gut integrity - avoid going on shift fasted Post-Incident Firefighters experience a toxic window post-fire when skin absorption is elevated due to heat, sweat, and vasodilation Strategic post-incident recovery can support detox efficiency: Immediate rehydration + electrolytes Protein to support glutathione and tissue repair Fruits/vegetables for antioxidant support Soluble and insoluble fiber to enhance GI elimination Avoid alcohol for ~24 hours as it impairs detox enzymes Non-Nutritional Strategies to Reduce Toxic Load 1
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[13] Transcription factors [edit] Peroxisome proliferator-activated receptor alpha (PPAR ) is a nuclear receptor that functions as a transcription factor