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Example: One patient from Arizona came to us because, despite being maximized on treatment for Rheumatoid arthritis with DMARDs and a biologic, her disease control was very poor

In animal models, C2 supplementation promoted neuroplasticity, synthesis of neurotrophic factors, modulation of glutamatergic dysfunction, reversal of neuronal atrophy in regions like the hippocampus and amygdala, and improvement in depression-like behavioral symptoms [20, 30, 57, 58]

It is usually well tolerated, but rare serious complications such as VPA-induced hepatotoxicity (VHT) and VPA-induced hyperammonaemic encephalopathy (VHE) may occur in some patients who receive VPA chronically [133]

Oral administration of ALC decreased VAS scores significantly

Appl Biochem Biotechnol 197 , 51865199 (2025)

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