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The supplemental approval is based on data from the Phase III PhALLCON trial, in which treatment with Iclusig led to superior MRD-negative complete remission rates and had comparable safety to Novartis Gleevec in adults with newly diagnosed Ph+ ALL

They may also help in the treatment of neurodegenerative conditions

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Front Pharmacol 16:1610429 Van De Weijer T, Schrauwen-Hinderling VB, Schrauwen P (2011) Lipotoxicity in type 2 diabetic cardiomyopathy

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