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Description

Some AMPs can chemoattract monocytes, dendritic cells (DC), T cells and neutrophils, etc, promoting the uptake and presentation of tumor cells by antigen-presenting cells and enhancing the immunogenicity of tumors

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By blocking TREK-1, PE-22-28: Increases neuronal excitability : Reduces potassium efflux, depolarizing neurons toward firing threshold Enhances serotonergic transmission : TREK-1 is expressed on serotonergic neurons in the dorsal raphe nucleus

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