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The production of NO by NOS2 (in micromolar amounts) is much higher and more sustained than by other NOSes, thereby making NOS2 an important player in regulating inflammation and infection ( 4 ) and ferrous iron (Fe 2+ )

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10.1016/j.eplepsyres.2023.107190 16 CovolanL.SmithR.MelloL

Its mechanism directly targets the inflammatory pathways involved in IBD

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