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The thioredoxin system: balancing redox responses in immune cells and tumors

It is comprised of TRX and thioredoxin reductase (TRXR), which work in concert to maintain a redox balance in the cellular environment via disulfide reduction of target proteins

Mar 2013;14(4):435-447

P.FreedmanM

Another double-blind, placebo-controlled clinical study with 24 participants used a 2% Ectoin cream twice a day for 4 weeks and found an improvement in all of the measured parameters, such as wrinkle volume, skin scaling, roughness, and elasticity

If you take one month course it will make the difference but 3 months course is better for too dark skin to improve at very bright level