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Overall, the available data support a cautious model in which mitochondria in the apical domain of PACs function as local ATP suppliers and Ca 2+ buffers that help maintain the secretory apparatus under physiological conditions, whereas mitochondrial failure in AP may indirectly destabilize the granule-rich apical region and facilitate pathological zymogen activation

Our approach enabled us to test four different hypotheses (Table 1) regarding the impact of preparation conditions on plasma GSH measures

The bidirectional pathways between the gut and the brain, known as the gut-microbiome-brain axis, have long been recognized

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GSH, a potent reducing agent, donates electrons to disulfide bonds in the nanogels, initiating a thiol-disulfide exchange reaction

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