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Wright DT, Cohn LA, Li H, Fischer B, Li CM, Adler KB: Interactions of oxygen radicals with airway epithelium

Four percent of the remaining acetaminophen dose is biotransformed by the hepatic cytochrome P-450 system

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In most studies, CYP activation is described as an upstream event leading to the production of reactive metabolites, which are themselves responsible for DNA adduct formation

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