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J Exp Bot 65(19):55355556

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However, you should contact your provider if you experience: Increasing redness or swelling Significant pain Warmth spreading beyond the injection area Pus or drainage Hard lumps that persist Skin discoloration that worsens over time These symptoms could indicate infection, inflammation, or an allergic response that requires medical evaluation

Additionally, common adverse effects, such as gastrointestinal discomfort including diarrhea, further reduce compliance (Chen Z