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51 Streptococcus thermophilus IDCC 2201 effectively lowers UA levels by degrading purine nucleosides, restoring intestinal flora, and promoting short-chain fatty acid production, making it a potential adjuvant treatment for HU

Erastin, as a small-molecule ferroptosis inducer, works by inhibiting the system Xc transporter-an amino acid antiporter responsible for exchanging extracellular cystine for intracellular glutamate (11)-leading to depletion of intracellular glutathione (GSH), indirectly inactivating glutathione peroxidase 4 (GPX4), and ultimately triggering ferroptosis (12)

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It can cause permanent neurological changes or fatigue

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