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Their relative efficacy depends on absorption, bioavailability, dose, duration, and individual hepatic capacityall factors that vary significantly across populations and genetic backgrounds

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Cytosolic glutathione S -transferases (GSTs) are a superfamily of enzymes that protect normal cells by catalyzing conjugation reactions of electrophilic compounds, including carcinogens, to glutathione

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Increased utility of the TCA and ETC is important for efficient ATP production

These changes were closely linked to reduced colonic inflammation and restored mucosal structure, indicating that the antioxidant action of triptolide contributed significantly to its protective effects in stress-related GI dysfunction