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Notably, certain commensals, like Clostridium cluster XIVa and segmented filamentous bacteria, have the ability to push the host immune system toward regulatory responses via regulatory Treg expansion and IL-10 production (Touchefeu et al., 2014)

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Individuals homozygous for the variant form (677TT) have an MTHFR enzyme with reduced affinity for its substrate (methylenetetrahydrofolate) and its riboflavin cofactor (FAD)

Oxidative stress can cause free radical chain reactions that lead to lipid peroxidation in both people and animals used in experiments