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Dizziness or Lightheadedness Frequency: Occasional (reported in 3-8% of users) Severity: Mild Duration: Minutes

The deacetylation of SHMT2 at K95 by SIRT3 (Wei et al., 2018) or desuccinylation at K280 by SIRT5 (Yang et al., 2018) has been shown to enhance the enzymatic activity of this protein, and the deacetylation by SIRT3 also has been shown to stabilize SHMT2 through avoiding its autophagic degradation (Wei et al., 2018)

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While preclinical studies demonstrate promising therapeutic potential, clinical outcomes may be influenced by factors such as patient variability, the TME, and tumor heterogeneity

Balancing risks: blood pressure targets, intradialytic hypotension, and ischemic brain injury