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Mechanistic target of rapamycin activation triggers IL-4 production and necrotic death of double-negative T cells in patients with systemic lupus erythematosus

Importantly, these subpopulations were also identified in vivo transplants, where the proportion of mature 1 cells was higher than in vitro cultures, underscoring the role of the physiological microenvironment in maintaining the mature -cell phenotype ( + influx

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In Achilles transection and ligament injury models, it counteracts corticosteroid impairment, elevates collagen deposition, and increases biomechanical strength

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In total, 48 subjects with PCa participated in the study