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10.1016/j.bmt.2023.01.005 128

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Weight loss injections approved by the FDA for chronic weight management include semaglutide (Wegovy) and tirzepatide (Zepbound)

It is therefore the spacing between the injections which is important

When leucine binds to Sestrin2, this inhibition is released, allowing GATOR2 to interact with other cellular machinery (Rag GTPases) to successfully localize and activate mTORC1 at the surface of the cell's lysosomes