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Molecular dynamics helps us narrow down particular regions that we want to focus on to develop therapeutics. The MIT team then used peptide synthesis technology that Pentelutes lab has previously developed, to rapidly generate a 23-amino acid peptide with the same sequence as the alpha helix of the ACE2 receptor

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A peptide with reduced acidity was designed for increased cell permeability The p53 TAD2 sequence exhibited a highly negative charge, whereas the p53 binding interface of the FOXO4 FHD contains several positively charged residues

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