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We and others also demonstrated that hemin induces the expression of NRF2 in SCD erythroblasts and animal models and such effect is mitigated by administration of dimethyl fumarate (DMF) 23,24 , an FDA-approved drug for the treatment of multiple sclerosis

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Recently, we demonstrated that 3MST produced H 2 S 2 and H 2 S 3 14

These complexes function as transcription factors that further localize to the nucleus and activate the expression of pro-angiogenic genes [103]