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Classification of volunteers in groups The volunteers were classified in the following groups ALL: all volunteers, M: males, F: females, S: all smokers, S_M: smokers males, S_F: smokers females, NS: all non-smokers, NS_M: non-smokers males, NS_F: non-smokers females, ES: all ex-smokers, ES_M: ex-smokers males and EX_F: ex-smokers females

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Reflexes Figure 3: Patient attending follow-up after biopsy at Sanus Medical Offices Laboratory tests: Cortisol AM: 4 g/dL (6.219.49) Adrenocorticotropic hormone (ACTH): 00 pg/mL (046) Total IgE (Immunoglobulin E): 1 IU/mL (087) Total vitamin D 25 OH (D3 + D2): 33 ng/mL Histopathology: Specimen: Abdominal skin: Skin from the edge of the umbilicus and skin from the left costal Procedure: Biopsy Histological type: Findings consistent with confluent and reticulated papillomatosis (GougerotCarteaud) Figure 4: Histopathological result of biopsy samples, responsible: Cristian Galarza S

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