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A consistent model goes with ligation leading to vessel injury, exposure of tissue factors, stasis, thrombosis, hemodynamic changes, arterial hypotension, and in particular, venous hypertension, which approximates values over 20 mm Hg in the inferior caval vein, thereby being roughly four times higher than those in normal rats

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The detrimental influence of senescence has been previously demonstrated

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In most instances, patients are advised to start a physical therapy program only after swelling is completely gone