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M., Haagsma, C

Intolerance to side effects: Decrease the dose to 50 mg for the next 4 weeks or consider discontinuing treatment with medical consultation

Experimental and clinical data suggest that melatonin exerts its anti-inflammatory effects by modulating both pro- and anti-inflammatory cytokines in various pathophysiological situations 73,74

Consequently, the GSH deprotonation step was considered non-rate-determining and thermodynamically favoured, leading us to use the GSH-thiolate as the starting point to compute the reaction mechanism for the conversion of flav-3-on-4-ol ( 7 ) into cyanidin ( 8-B4 ) in the wild-type enzyme and the C13S variant (Extended Data Fig

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