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It also augments the risk of type 2 diabetes and cardio-vascular diseases

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Other potential causes of vitamin B12 deficiency include surgical removal of the stomach or a portion of the stomach (gastrectomy), other gastrointestinal diseases such as celiac disease or Crohn's disease, infection, and poor nutrition

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The resulting systemic inflammation and immune activation further impair the BBB, facilitating the entry of neurotoxic substances into the brain ( Figure 9 )