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This remains a subject of scientific debate

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J Exp Bot 62(14):48434850

evaluated green tea extract (EGCG) taken orally as safe and effective treatment for symptomatic UFs [98]

Diabetes mellitus, which is a complication of obesity, can activate satellite glial cells of the supracervical ganglia through P2Y receptors, resulting in increased expression of pro-inflammatory cytokines such as IL-1, and causing oxidative damage to the autonomic nerves such as via an inflammatory response (111, 112) ( Figure 2 )

Mutation of His 18 to Ala abolished activity, consistent with the central role of His 18 in catalysis