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Abbreviations 3-HC: 3-Hydroxycotinine AUDIT: Alcohol Use Disorders Identification Test CAMH: Centre for Addiction and Mental Health CPD: Cigarettes per day CO: Carbon monoxide CYP2A6: Cytochrome P450 2A6 DASS 21: Depression, Anxiety and Stress Scale DAST-10: Drug Abuse Screening Test FTND: Fagerstrm Test for Nicotine Dependence ITT: Intention-to-treat principle mCEQ: Modified Cigarette Evaluation Questionnaire MNWS: Minnesota Nicotine Withdrawal Scale NMR: Nicotine metabolite ratio (3-HC/cotinine) NRT: Nicotine replacement therapy UOHI: University of Ottawa Heart Institute PHQ-9: Patient Health Questionnaire PPA: Point prevalence abstinence QI: Qualified investigator QSU-brief: Questionnaire of Smoking Urges - Brief SF-36: 36-Item Short-Form Health Survey References Government of Canada

The intensity and duration of the buzz can vary based on several factors, including nicotine content, consumption rate, and individual tolerance levels