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The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure

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Other GLP-1 and dual-agonist agents, including tirzepatide, are also in wide use, though not every GLP-1 on the market carries an FDA weight loss indication