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A missense variant in AIFM1 caused mitochondrial dysfunction and intolerance to riboflavin deficiency

Point mutations in ROGFP2 WT -PFGRX C32S/C88S , ROGFP2 C151S or ROGFP2 C208S were introduced by PCR with Pfu polymerase using ROGFP2 WT -PFGRX C32S /pET45b or ROGFP2 /pET28a as a template

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Many researchers even choose to inject near the site of injury, with the theory being that it increases local concentration while still providing a systemic effect

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The median increase of vitamin B12 levels in the non-responder group was 97 pmol/l (IQR: 78, 173) and in the responder group 934 pmol/l (IQR: 571, 1130)