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The biological explanation involves the somatostatin feedback system

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Xia Y, Hill KE, Li P et al (2010) Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects

J Endocr Soc 4(9):bvaa097