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Nature medicine, 2018;doi:10.1038/s41591-018-0092-9
Studying dose-response on one component while holding the other constant multi-arm protocols with separate vials
The preservation of normal glucose metabolism with AOD-9604 makes it potentially suitable for individuals with metabolic syndrome or diabetes risk factors who might not tolerate traditional GH therapy
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Peptide therapy, at its most rigorous, attempts to restore specific signaling functions that have degraded with time
A mixture of NO-driven LTP and/or LTD resulting from differences in transduction mechanisms setup by activity during the preceding wake period could also account for results suggesting both beneficial and paradoxically detrimental effects of sleep on learning and memory
