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Mechanistically, NNMT suppression increased adipose SAM and NAD, upregulated polyamine flux enzymes (ODC, SSAT), and altered histone methylation consistent with a shift toward oxidative metabolism [2]

Researchers have also investigated its contribution to experimental studies involving adipocyte biology, metabolic regulation, and intracellular energy pathways

Front Pharmacol 2020;11:1119

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Research into sulforaphanes impact on autism spectrum disorder (ASD) reveals a pattern of behavioral improvements during treatment, which tend to regress after the discontinuation of the compound