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Luminal contents can pass across the epithelial barrier via transcellular passive, active or endocytosis mechanisms, or via paracellular pathway

These anti-inflammatory effects make GHK-Cu relevant not just for acute shoulder injuries but for chronic conditions like tendinopathy where ongoing low-grade inflammation contributes to tissue degeneration

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GHK-Cu also modulates the expression of many genes associated with tissue remodeling microarray analyzes identified effects on over 4,000 genes